病原生物学安徽省重点实验室（安徽医科大学）
人畜共患病安徽高校省级重点实验室（安徽医科大学）
2013-2018年期间发表SCI论文
1．Lin Wang, He Chen, Daohua Liu, Xingxing Huo, Jiangmei Gao, Xiaorong Song, Xiucai Xu, Kaiquan Huang, Wenqi Liu, Yong Wang, Fangli Lu, Zhao-Rong Lun, Qingli Luo, Xuelong Wang, Jilong Shen. Genotypes and Mouse Virulence of Toxoplasma gondii Isolates from Animals and Humans in China. PLoS ONE, 2013 Jan, 8(1): e53483.
2．Tingting Liu, Qian Zhang, Lili Liu, Xiucai Xu, He Chen, Hua Wang, Lanting Kong, Weiwei Wang, Aimei Zhang, Yihong Cai, Min Li, Li Yu, Jian Du, Xuelong Wang, Qingli Luo, Zhao-Rong Lun, Yong Wang, Jilong Shen. Trophoblast apoptosis through polarization of macrophages induced by Chinese Toxoplasma gondii isolates with different virulence in pregnant mice. Parasitol Res, 2013 Aug, 112(8): 3019-3027.
3．Xing-Xing Huo, Lin Wang, Zhao-Wu Chen, He Chen, Xiu-Cai Xu, Ai-Mei Zhang, Xiao-Rong Song, Qing-Li Luo, Yuan-Hong Xu, Yu Fu, Hua Wang, Jian Du, Yi-Hong Cai, Zhao-Rong Lun, Fang-Li Lu, Yong Wang, Ji-Long Shen. Preventive effect of pidotimod on reactivated toxoplasmosis in mice. Parasitol Res, 2013 Aug, 112(8): 3041-3051.
4．Li Yu, Jilong Shen, Chunlei Su, Christine A. Sundermann. Genetic characterization of Toxoplasma gondii in wildlife from Alabama, USA. Parasitol Res, 2013 Mar, 112(3): 1333-1336.
5．Zhi-Jun Zhao, Jia Zhang, Jun Wei, Zhi Li, Tao Wang, Si-Qi Yi, Ji-Long Shen, Ting-Bao Yang, Geoff Hide, Zhao-Rong Lun. Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection. PLoS One, 2013 May, 8(5): e63650.
6．Bin Wu, Bo Huang, Ying Chen, Shaoyuan Li, Junping Yan, Huanqin Zheng,Shiguang Huang, Jilong Shen, Zhao-Rong Lun, Yong Wang, Lloyd H. Kasper, Fangli Lu. Upregulated expression of Tim-3 involved in the process of toxoplasmic encephalitis in mouse model. Parasitol Res, 2013 Jul, 112(7): 2511-2521.
7．Cui-Ping Ren, Peng Zhang, Wei-Na Zhang, Da-Ke Huang, Xue-Mei Jia, Li Gui, Miao Liu, Ji-Jia Shen. Schistosoma japonicum: Tsunagi/Y14 protein plays a critical role in the development of the reproductive organs and eggs. Exp Parasitol, 2013 Aug, 135(2): 430-436.
8．Lin Wang, Hua-Wei Cheng, Kai-Quan Huang, Yuan-Hong Xu5 Yong-Nian Li, Jian Du, Li Yu, Qing-Li Luo, Wei Wei, Ling Jiang and Ji-Long Shen. Toxoplasma gondii prevalence in food animals and rodents in different regions of China: isolation, genotyping and mouse pathogenicity. Parasites & Vectors, 2013 Sep, 6(1): 273.
9．Ai-Mei Zhang, Qian Shen, Min Li, Xiu-Cai Xu, He Chen, Yi-Hong Cai, Qing-Li Luo, De-Yong Chu, Li Yu, Jian Du, Zhao-Rong Lun, Yong Wang, Quan Sha and Ji-Long Shen. Comparative studies of macrophage-biased responses in mice to infection with Toxoplasma gondii ToxoDB #9 strains of different virulence isolated from China. Parasit & Vector, 2013 Oct, 6(1): 308.
10．Cai Y, Chen H, Jin L, You Y, Shen J. STAT3-dependent transactivation of miRNA genes following Toxoplasma gondii infection in macrophage. Parasites & Vectors, 2013 Dec, 6(1): 356.
11. W. Huang, Y. Qi, Y. Diao, F. Yang, X. Zha, C. Ren, D. Huang, K.L. Franken, T.H. Ottenhoff, Q. Wu, J. Shen, Use of resuscitation-promoting factor proteins improves the sensitivity of culture-based tuberculosis testing in special samples, Am J Respir Crit Care Med 189 (2014) 612-614.
12. M. Liu, Q. Wu, P. Chen, B. Buchele, M. Bian, S. Dong, D. Huang, C. Ren, Y. Zhang, X. Hou, T. Simmet, J. Shen, A boswellic acid-containing extract ameliorates schistosomiasis liver granuloma and fibrosis through regulating NF-kappaB signaling in mice, PLoS One 9 (2014) e100129.
13. D. Gao, J. Zhang, J. Zhao, H. Wen, J. Pan, S. Zhang, Y. Fang, X. Li, Y. Cai, X. Wang, S. Wang, Autophagy activated by Toxoplasma gondii infection in turn facilitates Toxoplasma gondii proliferation, Parasitol Res 113 (2014) 2053-2058.
14. Jian Du, Ran An, Lijian Chen, Yuxian Shen, Ying Chen, Li Cheng, Zhongru Jiang, Aimei Zhang, Li Yu, Deyong Chu, Yujun Shen, Qingli Luo, He Chen, Lijuan Wan, Min Li, Xiucai Xu, and Jilong Shen. Toxoplasma gondii Virulence Factor ROP18 Inhibits the Host NF-κB Pathway by Promoting p65 Degradation. J Biol Chem, 2014, 289: 12578-12592.
15. Min Li, Xu-Wei Mo, Lin Wang, He Chen, Qing-Li Luo, Hui-Qin Wen, Wei Wei, Ai-Mei Zhang, Jian Du, Fang-Li Lu, Zhao-Rong Lun and Ji-Long Shen. Phylogeny and virulence divergency analyses of Toxoplasma gondii isolates from China. Parasites & Vectors, 2014, 7:133.
16. Yihong Cai, He Chen, Xuwei Mo, Yuanyuan Tang, Xiucai Xu, Aimei Zhang, Zhaorong Lun, Fangli Lu, YongWang, Jilong Shen. Toxoplasma gondii inhibits apoptosis via a novel STAT3-miR-17-92-Bim pathway in macrophages. Cellular Signalling, 2014, 26: 1204-1212.
17. Lun ZR, Lai DH, Wen YZ, Zheng LL, Shen JL, Yang TB, Zhou WL, Qu LH, Hide G, Ayala FJ. Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii. Proc Natl Acad Sci USA, 2015, 112(29): 8835-8842.
18. Cheng W, Liu F, Li M, Hu X, Chen H, Pappoe F, Luo Q, Wen H, Xing T, Xu Y, Shen J. Variation detection based on nextgeneration sequencing of type Chinese 1 strains of Toxoplasma gondii with different virulence from China. BMC Genomics, 2015, 16: 888.
19. Chang W, Ding D, Zhang S, Dai Y, Pan Q, Lu H, Luo Q, Shen J, Ma X. Methicillin-Resistant Staphylococcus aureus Grown on Vancomycin- Supplemented Screening Agar Displays Enhanced Biofilm Formation. Antimicrob Agents Chemother, 2015, 59(12): 7906-7910.
20. Zhou J, Gan X, Wang Y, Zhang X, Ding X, Chen L, Du J, Luo Q, Wang T, Shen J, Yu L. Toxoplasma gondii prevalent in China induce weaker apoptosis of neural stem cells C17.2 via endoplasmic reticulum stress (ERS) signaling pathways. Parasit Vectors, 2015, 8: 73.
21. Wang L, He LY, Meng DD, Chen ZW, Wen H, Fang GS, Luo QL, Huang KQ, Shen JL. Seroprevalence and genetic characterization of Toxoplasma gondii in cancer patients in Anhui Province, Eastern China. Parasit Vectors, 2015, 8: 162.
22. Hou X, Song J, Su J, Huang D, Gao W, Yan J, Shen J. CD4+Foxp3+Tregs protect against innate immune cell-mediated fulminant hepatitis in mice. Mol Immunol, 2015, 63(2): 420-742.
23. Kong L, Zhang Q, Chao J, Wen H, Zhang Y, Chen H, Pappoe F, Zhang A, Xu X, Cai Y, Li M, Luo Q, Zhang L, Shen J. Polarization of macrophages induced by Toxoplasma gondii and itsimpact on abnormal pregnancy in rats. Acta Trop, 2015, 143: 1-7.
24. Diao Y, Hua M, Shao Y, Huang W, Liu M, Ren C, Ji Y, Chen J, Shen J. Preliminary characterization and expression of Vasa-like gene in Schistosoma japonicum. Parasitol Res, 2015, 114(7): 2679-2687.
25. Zhang Y, Huang D, Gao W, Yan J, Zhou W, Hou X, Liu M, Ren C, Wang S, Shen J. Lack of IL-17 signaling decreases liver fibrosis in murine schistosomiasis japonica. Int Immunol, 2015, 27(7):317-325.
26. Xu X, He L, Zhang A, Li Q, Hu W, Chen H, Du J, Shen J. Toxoplasma gondii isolate with genotype Chinese 1 triggers trophoblast apoptosis through oxidative stress and mitochondrial dysfunction in mice. Exp Parasitol, 2015, 154: 51-61.
27. Zhang Q, He L, Kong L, Zhang Y, Chen H, An R, Wang L, Wang W, Xu X, Zhang A, Cai Y, Li M, Wen H, Luo Q, Shen J. Genotype-Associated Arginase 1 Expression in Rat Peritoneal Macrophages Induced by Toxoplasma gondii. J Parasitol, 2015, 101(4): 418-423.
28. Zheng S, Lu Q, Xu Y, Wang X, Shen J, Wang W. GdCl3 Attenuates Schistosomiasis japonicum Egg-Induced Granulomatosis Accompanied by Decreased Macrophage Infiltration in Murine Liver. PLoS One, 2015, 10(8): e0132222.
29.Wu Q, Nie J, Gao Y, Xu P, Sun Q, Yang J Han L, Chen Z, Wang X, Lv L, Tsun A, Shen J, Li B. Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1. Sci Rep, 2015, 5: 16355.
30. Wan L, Gong L, Wang W, An R, Zheng M, Jiang Z, Tang Y, Zhang Y, Chen H, Yu L, Shen J, Du J. T. gondii rhoptry protein ROP18 induces apoptosis of neural cells via endoplasmic reticulum stress pathway. Parasit Vectors, 2015, 8: 554.
31. Wang S, Xie Y, Yang X, Wang X, Yan K, Zhong Z, Wang X, Xu Y, Zhang Y, Liu F, Shen J. Therapeutic potential of recombinant cystatin from Schistosoma japonicum in TNBS-induced experimental colitis of mice. Parasit Vectors, 2016, 9: 6.
32. Gan X, Zhang X, Cheng Z, Chen L, Ding X, Du J, Cai Y, Luo Q, Shen J, Wang Y, Yu L. Toxoplasma gondii inhibits differentiation of C17.2 neural stem cells through Wnt/β-catenin signaling pathway. Biochem Biophys Res Commun, 2016, 473(1): 187-93.
33. Hou X, Hao X, Zheng M, Xu C, Wang J, Zhou R, Tian Z. CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with Kupffer cells. Cell Mol Immunol, 2016, doi: 10.1038/cmi.2015.111. [Epub ahead of print]
34. Xie Y, Wen H, Yan K, Wang S, Wang X, Chen J, Li Y, Xu Y, Zhong Z, Shen J, Chu D. Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica. Cell Mol Immunol. 2018 Feb;15(2):120-134.
35. Deng YR, Liu WB, Lian ZX, Li X, Hou X. Sorafenib inhibits macrophage- mediated epithelial-mesenchymal transition in hepatocellular carcinoma. Oncotarget, 2016, 7(25): 38292-38305.
36. Liu F, Cheng W, Pappoe F, Hu X, Wen H, Luo Q, Wang S, Deng F, Xie Y, Xu Y, Shen J. Schistosoma japonicum cystatin attenuates murine collagen-induced arthritis. Parasitol Res, 2016, 115(10): 3795-806.
37. Liu Y, Li T, Xu Y, Xu E, Zhou M, Wang B, Shen J. Effects of TLR4 gene silencing on the proliferation and apotosis of hepatocarcinoma HEPG2 cells. Oncol Lett, 2016, 11(5): 3054-3060.
38. Dai C, Zhang C, Sun X, Pan Q, Peng J, Shen J, Ma X. LukS-PV induces differentiation by activating the ERK signaling pathway and c-JUN/c-FOS in human acute myeloid leukemia cells. Int J Biochem Cell Biol, 2016, 76: 107-14.
39. Zhang X, Su R, Cheng Z, Zhu W, Li Y, Wang Y, Du J, Cai Y, Luo Q, Shen J, Yu L. A mechanistic study of Toxoplasma gondii ROP18 inhibiting differentiation of C17.2 neural stem cells. Parasit Vectors, 2017, 10(1): 585.
40. Cheng W, Wang C, Xu T, Liu F, Pappoe F, Luo Q, Xu Y, Lu F, Shen J. Genotyping of polymorphic effectors of Toxoplasma gondii isolates from China. Parasit Vectors, 2017, 10(1): 580.
41. Tang Y, Zheng M, An R, Chen L, Gong L, Cai H, Liu K, Yu L, Shen J, Du J. Proteasomal degradation of T. gondii ROP18 requires Derlin2. Acta Trop, 2017, 174: 106-113.
42. Pappoe F, Cheng W, Wang L, Li Y, Obiri-Yeboah D, Nuvor SV, Ambachew H, Hu X, Luo Q, Chu D, Xu Y, Shen J. Prevalence of Toxoplasma gondii infection in HIV-infected patients and food animals and direct genotyping of T. gondii isolates, Southern Ghana. Parasitol Res, 2017, 116(6): 1675-1685.
43. Li Y, Poppoe F, Chen J, Yu L, Deng F, Luo Q, Xu Y, Cai Y, Shen J. Macrophages Polarized by Expression of ToxoGRA15II Inhibit Growth of Hepatic Carcinoma. Front Immunol, 2017, 8: 137.
44. Xing T, Wang Y, Ding WJ, Li YL, Hu XD, Wang C, Ding A, Shen JL. Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-κB Signaling Pathway. Inflammation, 2017 Oct; 40(5): 1606-1621.
45. He S, Zhu L, Liu F, Liu Q, Shao Y, Hua M, Ding H, Shao W, Du Y, Hou X, Ren C, Liu M, Shen J. Functions of the Vasa gene in Schistosoma japonicum as assessed by RNA interference. Gene, 2018, 638: 13-19.
46. Li M, Gao Y, Yong L, Huang D, Shen J, Liu M, Ren C, Hou X. Molecular signature and functional analysis of uterine ILCs in mouse pregnancy. J Reprod Immunol, 2017, 123: 48-57.
47. Yong L, Li M, Gao Y, Deng Y, Liu W, Huang D, Ren C, Liu M, Shen J, Hou X. Identification of pro-inflammatory CD205+ macrophages in livers of hepatitis B virus transgenic mice and patients with chronic hepatitis B. Sci Rep, 2017, 7: 46765.
48. Hou X, Hao X, Zheng M, Xu C, Wang J, Zhou R, Tian Z. CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with Kupffer cells. Cell Mol Immunol, 2017, 14(8): 675-684.
49. Ding H, Liu F, Zhu L, Wu F, Liu Q, He S, Shao W, Du Y, Ren C, Shen J, Liu M. Tyrosine kinase 4 is involved in the reproduction of the platyhelminth parasite Schistosoma japonicum. Parasit Vectors, 2017, 10(1): 498.
50. Liu Q, Zhu L, Liu F, Hua M, Ding H, He S, Ren C, Liu M, Shen J. Function of Nanos1 gene in the development of reproductive organs of Schistosoma japonicum. Parasitol Res, 2017, 116(5): 1505-1513.
51. Yao Y, Liu M, Ren C, Shen J, Ji Y. Exogenous tumor necrosis factor-alpha could induce egress of Toxoplasma gondii from human foreskin fibroblast cells. Parasite, 2017, 24:45.
52. Li Z, Guo Q, Zheng L, Ji Y, Xie YT, Lai DH, Lun ZR, Suo X, Gao N. Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii. Cell Res, 2017, 27(10): 1275-1288.
